In first study, led by researchers at University College London, scientists performed deep genome sequencing on liver tissue samples from five children who needed transplants because of unexplained hepatitis.
"They are viruses that merit about one line in very small print in the largest textbooks, so I've never come across them as a cause of disease," said Will Irving, a virologist at the University of Nottingham. Researchers say this finding has them scratching their heads. So they depend on a cells being infected at the same time with a helper virus, and the helper is usually adenovirus."īecause they're thought to be mostly inert on their own, adeno-associated viruses are being studied as vehicles for gene therapy.īeyond that, scientists say, not much is known about them. And by themselves when they infect cells, they're unable to grow because they don't encode all of the functions required for the replication. Gary Ketner, a molecular microbiologist at Johns Hopkins University who specializes in the study of adenoviruses, describes them as "very small, DNA-containing viruses. It's got to have a host virus," said Alex Greninger, assistant director of the clinical virology laboratory at the University of Washington. "A remora is not like the best analogy, but it's sort of like that. Virologists say they're kind of like remoras, the fish that attach themselves to sharks and eat the leftovers of their meals. They belong to a family of viruses called dependoparvoviruses. And it was only rarely found in healthy kids, those with only adenovirus infections but no liver damage, or those who had liver damage with a clear cause.Īdeno-associated viruses are tiny bits of DNA they can't copy themselves until they're in the presence of another virus, usually adenovirus or herpes. In two new studies, scientists say they may have found a smoking gun in adeno-associated virus 2, which is different from advenovirus 41.Īdeno-associated virus 2 was present in high amounts in liver tissue and blood in nearly all the children with unexplained hepatitis in the studies. Continued abuse of our services will cause your IP address to be blocked indefinitely.Most of the children who tested positive had low levels of adenovirus in their blood and no adenovirus infection in their livers, leading many doctors to suspect another cause such as Covid-19, or a complicating factor like genes or an environmental exposure. Please fill out the CAPTCHA below and then click the button to indicate that you agree to these terms. If you wish to be unblocked, you must agree that you will take immediate steps to rectify this issue. If you do not understand what is causing this behavior, please contact us here.
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